The original Rag Doll Kung Fu was an independently developed (by the now “game of the year”-famous makers of Little Big Planet) drug infested rag doll fighting game. It was blasting with marijuana leaves, explicit mushroom abuse and colorful space and time bending effects. I would say it was THE stoner-movie among video games.
You can still play it and there is a free-to-play demo available. Check out the games homepage.